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New members of the APT family, such as ABHD10 and ABHD17, belong to the / hydrolase superfamily, suggesting a broader depalmitoylase landscape beyond the canonical APT1 and APT2 (48)

4.2 Ferroptosis and rheumatoid arthritis Rheumatoid arthritis (RA) is the typical autoimmune disease that primarily targets the synovial membrane of the joints, resulting in the synovium transforming into a hyperplastic and invasive tissue that destroys cartilage and bone (128)

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similar to fatty acid biosynthesis Modular complexes of enzymes for recognition, activation, modification and condensation of a specific amino acid to the growing polymer Features use of unusual amino acids, D-enantiomers, and non- peptide bonds Peptidoglycans, antibiotics and ionophores Reactions with Pyridoxal Phosphate Amino acid racemase reactions L-alanine D-alanine Inhibitors of alanine racemase: Antibiotics peptidoglycan biosynthesis Biosynthesis of Plant Compounds phenylalanine, tyrosine, tryptophan precursors for plant compounds: lignin (phenolic polymer) indole-3-acetate (auxin) tannins alkaloids, e.g