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Iron deficiency occurs when dietary intake is insufficient, when absorption in the gastrointestinal tract is impaired, when demand is increased (accelerated growth, pregnancy), or as a consequence of blood loss

While everyone needs B12, some populations are at greater risk for deficiency

According to NICE Clinical Knowledge Summary guidance, patients with neurological involvement should receive more intensive initial treatment to optimise recovery potential

and a likely soluble form of CD38 present in the cytoplasm (Figure 1)