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Therefore, intranasal administration has attracted considerable research interest as an alternative method to conventional parenteral and oral routes, because it can increase the drug concentrations in the brain by direct nose-to-brain delivery via olfactory and trigeminal nerve pathways

These modifications alter the DNA binding affinity and, thus, allow it to regulate a host of cellular pathways such as oxidative stress signaling

Below ~10 units, a 30- or 50-unit syringe improves accuracy

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