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Increased endoplasmic reticulum stress and reactive oxygen species (ROS) production are important mediators in inducing ICD (34)

This leads to further recruitment of systemic inflammatory cells, such as neutrophils, T-cells, and monocytes into the liver, which perpetuate additional inflammation and the development of progressive liver damage

This lowers T-cell infiltration, which decreases the entry of other immune system components that destroy nerve cells [29, 30]

Furthermore, losartan treatment enhanced the activity of key antioxidant enzymes, including superoxide dismutase and catalase

Oliveira N, Leal R, Dantas T (2015) The importance of the cashew nut ( Anacardium occidentale L.) coat: a review