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(36) found no significant liver enzyme improvement in pediatric patients, primarily based on a single pediatric study that itself showed no clear benefit (68)
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Of the dozens of known mutations, four SOD1 , chromosome 9 open reading frame 72 ( C9orf72 ) hexanucleotide repeat expansion (HRE), transactive response DNA binding protein ( TARDBP ), and FUS are most prevalent [14, 15]
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