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Likewise, SIRT3 acts as a core regulatory enzyme of mitochondrial metabolism to mediate mitophagy and suppress the accumulation of advanced glycation end-products, thereby delaying bone marrow-MSC senescence and maintaining bone homeostasis (168)

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Eventually, when telomeres become critically short, the cell enters senescence: an irreversible state of growth arrest linked to aging and disease [22]

However, the metabolic enhancement 5-amino-1mq provides may make a given caloric deficit more effective, meaning faster results without more extreme restriction

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