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It is known that a widespread characteristic of tumors is their inability to develop adequate blood vessels with the consequence being relative hypoxia: at moderate levels, ROS induce transcription of HIF1, the founding member of the family of hypoxia-induced factors, and stabilize the encoded protein, which is normally hydroxylated within less than 5 min, by inhibiting the activity of the iron-dependent prolyl 4-hydroxylase (PHD) involved in its degradation 29

For an experimental insight into the dynamic intracellular stabilization and translocation of Nrf2 in live cells, Nrf2, heme oxygenase 1 (HMOX1), and sulfiredoxin (SRXN1) monoclonal HepG2-based BAC-GFP reporter lines (Wink et al

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