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The neuroprotective effects of the ketogenic diet further extend to synaptic plasticity regulation: by increasing -hydroxybutyrate (BHB) levels, it directly activates the ERK/CREB signaling pathway in the hippocampus, promoting brain-derived neurotrophic factor (BDNF) synthesis (especially in females) to restore impaired long-term potentiation (LTP) in Alzheimers model mice

Thats more than 20 basis points higher than the Dows 19.81%, as tracked by the SPDR Dow Jones Industrial Average ETF (DIA), and nearly 15 basis points higher than the S&P 500s 24.70%, as tracked by the SPDR S&P 500 ETF (SPY), over the same period, data show

ALDH1L2 loss elevates ROS and promotes ADM in a model of pancreatitis and accelerates tumour progression in models of pancreatic cancer

Amino acid deprivation triggers the integrated stress response (ISR) through GCN2, which detects uncharged tRNAs and phosphorylates translation initiation factor eIF2 19