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Areas requiring further investigation include: Tissue-specific dose optimisation: While 10-20 g/kg appears broadly effective across various tissues, whether specific tissues (cartilage versus muscle versus nerve) respond optimally to different doses has not been systematically explored

Protocols typically run in 46 week blocks

This includes maintaining a balanced diet, engaging in regular exercise (as appropriate for your condition), ensuring adequate sleep, and managing stress levels

Gene-level modulation: Pickart & Margolina 2018 documented activity across ~4,000 human genes, with fibroblast expression patterns shifting closer to younger cells