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Clinically, in patients with renal failure, acute kidney injury, dialysis and other pathological states of renal function deterioration, renal reabsorption function is impaired, resulting in a significantly lower serum free carnitine concentration than that in healthy people [255], and the metabolic profile of acylcarnitine also changes significantly [256]

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Primary carnitine deficiency is a rare metabolic disorder in which an abnormal gene prevents the body from using certain fats for energy, particularly during long periods without food

Relative bioavailability (AUC plasma /dose) was 19 2%

The treatment with L-carnitine was also shown to decrease MDA level and to increase SOD and glutathione peroxidase activity [25]