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By utilizing various metabolites as co-factors, histone methyltransferases (HMTs), histone demethylases (HDMs), histone acyltransferases (HATs), and histone deacetylases (HDACs) are modifying histones to form either heterochromatin or euchromatin and to recruit other regulatory protein complexes and transcription factors

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Although SMA had long been an incurable disease, the development of new drugs changed the lives of patients with SMA at the beginning of 21st century