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Introduction: Introduction: AOD-9604 is a synthetic peptide fragment of human growth hormone (hGH 177191) engineered to replicate hGHs fat-metabolism effects without altering IGF-1 or glucose levels. In preclinical research, it promoted lipolysis (fat breakdown) and reduced lipogenesis (fat storage) through receptor-independent mechanisms. AOD-9604 Fast Facts Class: Synthetic hGH fragment analog (Tyr-hGH 177191) Intended purpose: Stimulate fat metabolism while avoiding hGHs growth or glucose effects Mechanism: Increases fat oxidation, enhances lipolysis, suppresses lipogenesis Distinct from hGH: Does not activate the growth hormone receptor or raise IGF-1 Development stage: Completed Phase II trials

What are the main benefits of using HGH fragment 176 191

FDR, false discovery rate

This study analysed a group of Dutch Caucasians with a polymorphism in the promoter of the IGF-1 gene [129, 218]

Endocrinology 148 (10), 46584666