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Research has demonstrated that thiamine supplementation can ameliorate symptoms of diabetic neuropathy by improving nerve conduction velocity and reducing oxidative stress, which is often elevated in neuropathic conditions
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Hydroxyl radical (OH) directly generated from the Fenton reaction abstracts a hydrogen from PUFAs, forming a phospholipid carbon-centered radical (PL), and proceeding with the oxygen addition to peroxyl radical (PL-OO) to yield a phospholipid hydroperoxide (PL-OOH)
