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Simultaneously, macrophage differentiation shifts from the M2 pole (pro-resolving macrophages) toward the pro-inflammatory M1 pole (metabolically activated macrophages in meta-inflammation)

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TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy

Yes, certain peptides like BPC 157 are known to promote tissue regeneration and reduce inflammation, which can help heal lower back pain by addressing the underlying causes of discomfort