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neoformans can then convert catecholamines (dopamine, norepinephrine, and epinephrine) found in the CNS into melanin, further fortifying it from host defenses and advancing disease severity

It also works in tandem with iodine to maintain a balanced thyroid

For example, clinical cases of vitamin B12 deficiency have been reported even in persons with low-to-normal total serum vitamin B12 levels (Lindenbaum et al., 1988)