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A role for the P2Y11, a GPCR purino-receptor leading to a rise in both intracellular cAMP (stimulation of adenylate cyclase [AC]) and calcium mobilization (increased inositol 3 phosphate [IP3]) has been demonstrated upon exposure of CF airway epithelia cells to LXA4 ( Figure 5 ) (Verrire et al., 2012

doi: 10.1016/j.jddst.2023.104876 178

SOD is a metalloenzyme and hence, requires a metal cofactor for its activity

Dry eye disease (DED) is progressively impacting an increasingly large global population, with its etiology encompassing ocular surface inflammation and oxidative stress [239]