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The effects of pH on the other types of investigated surfactants, however, were considerably less pronounced: for non-ionic surfactants, itraconazole showed an increase in solubility somewhat at pH = 3 compared to pH = 6.5
PMID: 42 YangXZhangZShenXXuJWengYWangWet al

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Addressing the problem while tissue retains regenerative capacity offers better outcomes than waiting until degeneration becomes established
