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ICH Q13 and ISO/TR 10993-22 provide a framework-based guidance from different perspectives but complementing each other [241]

A extrapolao dessas doses para humanos, utilizando os fatores de converso alomtricos padro (fator de 6,2 para o rato), fornece doses tericas da ordem de 1,6 g/kg em humanos

Eur J Nutr 60:23432360

[DOI] [PMC free article] [PubMed] [Google Scholar] 193.Chang X, Zhu Y, Shi C, Stewart AK

Remain active with your exercise but do not get over-heated
