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On the other hand, Type B reactions, nearly 20 % of the reactions, are unpredictable, rare, and dose-independent reactions, which are not owing to the pharmacologic nature of a drug [5]

Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47 null cells
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Additionally, inflammatory signals and the overload in intracellular calcium ion could be also implicated in this complex network that has not yet been elucidated

Supplementary Data 5, Sheets 34)
