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However, before discovering the necessity to carry out an insulin stimulus in order to increase muscle carnitine reserves, some studies [9,21,22] found lower accumulation of blood lactate concentration and an increase in O 2 and work capacity after oral l-C supplementation without insulin stimulus, particularly in high-intensity exercises [46,47]

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Whereas, the increase from rest with placebo was only 4% and 6% at 3 and 10 minutes post protocol, respectively (Figure 1)