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H 2 O 2 output rises with high secretory load and activation of the unfolded protein response (UPR^ER) and is further modulated by Ca fluxes as well as mono-oxygenase systems such as cytochrome P450 and cytochrome b reductase (Roscoe and Sevier 2020)

In addition, PrfA thiols may be reversibly oxidized, temporarily inactivating the protein by inhibiting DNA binding and leading to a downregulation of PrfA-regulated genes (PRG)

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Another study in vitro showed that curcumin could arrest endometriotic cells proliferation in a dose-dependent manner by repressing the activity of matrix metalloproteinase-9 (MMP-9), a factor involved in tissue remodeling