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While weight loss correlates with steatohepatitis resolution, the relationship is imperfect, and even semaglutides phase 2 trial failed to move fibrosis despite clear NASH resolution a reminder that steatosis, inflammation, and fibrosis do not always respond in lockstep

Epub 2017 Jun 15 Lim PJ, Lindert U, Opitz L, Hausser I, Rohrbach M, Giunta C

This makes results more predictable and effective

Immune modulation: KPV modulates the immune response without suppressing it it reduces excessive inflammation while preserving the body's defense capacity

These receptors are part of the central nervous systems pathway for processing pain signals