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Over the last decade, many GWAS have also reported that the variants at GSTP1 gene cluster were associated with plasma HDL, LDL, ApoA1 concentration and diastolic blood pressure [94, 95, 97]
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Aluminum is a known neurotoxin
Peptide therapies should be used with medical supervision to avoid complications, ensure appropriate dosing, and monitor for side effects
Thus, we hypothesise that selection on GPX1-6 may favour seleno-dependent GPXs (i.e., extreme phenotype) that is harder to encode but exhibits greater efficiency
