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PDTAC: targeted photodegradation of GPX4 triggers ferroptosis and potent antitumor immunity

Moreover, cyclooxygenase inhibitors, which suppress prostaglandin E2 synthesis, have been shown to reduce fungal biofilm formation, highlighting their potential as adjunctive agents in antifungal therapy ( 4.4 Antifungal drugs targeting metabolic pathways and enzymes Fungal metabolism involves a wide array of biochemical pathways essential for growth, survival, and virulence, including N-acetylglucosamine utilization, trehalose metabolism, lipid biosynthesis, energy production, and intracellular transport (Pan et al., 2018

The Trp-independent pathway is less well understood than the Trp-dependent pathway, which is the well characterized pathway that uses tryptophan as a precursor for IAA
