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The stacking approach is the most common protocol in the research community for this reason

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Furthermore, according to a randomized trial conducted in a population of patients with T2D receiving metformin for at least 4 years and experiencing diabetic neuropathy, administration of 1 mg oral methylcobalamin for 1 year was associated with a significant improvement in neurophysiological parameters and scores assessing neuropathic pain and quality of life [58]