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10.1111/jpn.12070 106
10.1016/j.ejps.2016.03.017 116 ZhengS.LiuC.TangD.ZhengZ.YanR.WuC.et al (2022)
The study found that histone acetylation (H3K14ac) in NAc was temporarily reduced after chronic social defeat stress and then continued to increase with a decrease in HDAC2 levels, as was also observed in postmortem brain tissue NAC of depressed patients
These findings emphasize the importance of rigorous in vivo validation using immunocompetent models and careful consideration of off-target effects
Post-treatment care is important
