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Cardiac ECs also have a larger Golgi apparatus, fewer vesicles, and higher metabolic activity than vascular ECs [20, 24]

In the brain, for example, increased oxidative damage to neurons and glia is implicated in age-related cognitive decline and neurodegenerative diseases

According to a 2014 review published in The Lancet: Diabetes & Endocrinology , loss of muscle mass and strength is an important risk factor for accelerating rates of physical disability, hospitalization, and death in the older population, and is associated with the progressive health implications of diabetes, obesity, hyperthyroidism, hypercortisolism, vitamin D deficiency, osteoporosis, rheumatoid arthritis, COPD, congestive heart failure, renal disease and more

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