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This heterogeneity results from the inter-cellular variability in abundance of the corresponding ion transport pathways [NMDA receptors, voltage-gated Ca 2+ channels (Cav2.1), and LPA receptors] in RBC of healthy humans (Makhro et al., 2013

Despite these findings, the majority of published data remains preclinical and comes from rodent and animal models, rather than human trials

NF- proteins are produced through the proteolytic processing of two other precursor proteins, p100 and p105

Insufficient protein during rapid weight loss leads to muscle wasting, which worsens fatigue, reduces metabolic rate, and produces the "skinny fat" outcome nobody wants

Based on this report, the MDT committee integrated by the medical coordination team, the clinical geneticists, the bioinformaticians, the precision medicine and clinical genomics expert, the nutritionist trained in genetics, and the relevant phenotype-specific specialist, reviews the findings collaboratively