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Some research has suggested a possible connection between L-carnitine supplementation and increased risk of atherosclerosis, a condition in which the arteries harden due to buildup of fats, cholesterol, and other substances

What was also statistically significant was the benefit of L-carnitine supplementation for specific subgroups of subjects

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Interestingly, the researchers noted that combining the two forms resulted in less overall improvement than using them individually, suggesting a potential competition for intestinal absorption or cellular transport mechanisms