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Although members of the CGFS (class II) sub-family are sometimes referred to as monothiol GRX, in at least some cases catalytic activity involves formation of an intramolecular disulfide bond with a second cysteine located distally from the GRX active site motif

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Additionally, recent studies suggest that a high sugar diet can alter the gut microbiota leading to age-associated illness 6,7,8,9