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KD was shown to slow tumor growth in immunocompromised mice that had genetically and metabolically differentiated melanoma xenografts, indicating that it can inhibit tumor progression regardless of the genetic basis of the tumors
Ferroptosis is particularly prominent in metabolic diseases, with its manifestation being more pronounced in DCM

Cytokine signaling 1 (SOCS1) is required for p53 activation and the regulation of cellular senescence, and SOCS1 is sufficient to regulate the expression of p53 target genes and sensitized cells to ferroptosis by reducing the expression of the cystine transporter SLC7A11 and the levels of GSH (Saint-Germain et al., 2017)

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