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Formation of thioethers at cysteine-553, such as with the lipid peroxydation biomarker 4-HNE inhibits the formation of the GCLC(S-S)GCLR holo-enzyme and results in a decrease of GSH production

L., Chang J

[DOI] [PMC free article] [PubMed] [Google Scholar] 143.Atay S., Godwin A.K

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Heme oxygenase-1 (HMOX1) safeguards the cellular redox balance and has been demonstrated to reduce cisplatin-induced nephrotoxicity by safeguarding cellular redox, induction of which could also be a part of the bismuth-induced mitigative effect (Schaaf et al., 2002)
