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Exposure to pristane for 12 or 24 weeks promoted macrophage activation syndrome, characterized by hemophagocytosis in spleen and peripheral blood, as well as hypercytokinemia of IFN-, TNF-, IL-4, and IL-6

Why does PCO still develop at appreciable rates years after surgery PCO development during the first year post-surgery likely results from the LEC response to the numerous cell signaling pathways acutely induced by surgery leading to changes in cell behavior that induce them to enter the optical axis (199)

Safety data in humans are restricted to short-term topical or local use with mild adverse reports

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