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MTHFR also plays a central role in the transformation of folate to S-adenosylmethionine (SAM), the universal methyl donor in cells and affects DNA methylation status

doi: 10.1080/07315724.2020.1789518 30 JainS
These representative data could be influenced by different environmental circumstances

10.1016/j.freeradbiomed.2015.06.019 Free Radic Biol Med

USA 117 , 2759827607 (2020)