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Short-term oral administration of mesoporous silica nanoparticles potentially induced colon inflammation in rats through alteration of gut microbiota

A major barrier is their poor bioavailability, attributed to rapid metabolism, limited systemic retention, and restricted penetration of the bloodbrain barrier, necessitating the development of advanced delivery platforms such as nanoformulations, liposomes, or prodrugs to enhance central nervous system targeting (Iqbal et al

Amylin suppresses acetic acid-induced visceral pain and spinal c-fos expression in the mouse

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