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it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 5052
Mishra A, Goel RK (2016) Chronic 5-HT3 receptor antagonism ameliorates seizures and associated memory deficit in pentylenetetrazole-kindled mice
Front Immunol 13:943321 Dai H et al (2018) Sirtuin activators and inhibitors: promises, achievements, and challenges
The first reaction is rate limiting and is catalyzed by the enzyme glutamate-cysteine ligase (GCL, EC 6.3.2.2
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