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Besides the aforementioned complex neuroendocrine interactions, a proper adrenal gland GC response during stress depends on the availability of cholesterol the major substrate for steroidogenesis [67], hereditary factors [68], and the crosstalk between multiple cell types coexisting in the adrenal microenvironment, such as adrenocortical, chromaffin, endothelial, neuronal, immune, and glial cells [69, 70]

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The rat GS promoter contains functional AP-1 sites, some of which act as enhancers

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Quality of Individual Studies and Determination of Evidence Strength Quality of individual studies that were RCTs or crossover trials was assessed using the Cochrane Risk of Bias tool