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Description
Most patients undergoing CAR T-cell therapy have been on long-term immunosuppressive treatments (such as corticosteroids, cyclophosphamide, tacrolimus, and rituximab) to control their condition, which can severely impair T cell quantity and function
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NACAs characteristics as a drug were improved over NAC by neutralizing the carboxylic group of NAC, which makes the NACA pass cellular membranes easily, says Ercal

L., Zhuo, D

doi: 10.1084/jem.20181776
