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Introduction Diabetes mellitus remains one of the leading causes of deaths worldwide (Figure 1) ( FIGURE 1 There has been a general interest in pharmacological compounds with strong antioxidant and anti-inflammatory properties for their protective effects against diabetes-associated cardiovascular complications ( There is currently a considerable interest in understanding the therapeutic role of herbs and supplements against diabetes and CVD-related complications ( Methodology Supplementary file 1 contains the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines that were followed to prepare the manuscript

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Potential therapeutic benefits of NAC include, extracellularly scavenging ROS radicals, replenishing intracellular GSH, suppression of cytokine storm, and T cell protection, thus mitigating inflammation and tissue injury

The researchers administered 500 mg of bioavailable curcumin twice daily for 4 weeks