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18 The phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) is triggered by the dissociation of ASK1 from Trx, resulting in ASK1 activation (Fig

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This reprogramming involves the downregulation of genes associated with proinflammatory responses and resistance to tissue invasion, along with the upregulation of genes that enhance cell proliferation, promote tolerance, and support tissue invasion ( As previously mentioned, one of the hallmarks of ferroptosis is iron accumulation