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doi: 10.3390/polym13162815

During HBs specification, the pioneer factors recruit EZH2, a histone methyltransferase (KMTs) that catalyzes histone three lysine 27 (H3K27) me3, to silent pancreatic-specific genes in HBs (Tachmatzidi et al., 2021), which exerts unique functions in liver-specific gene activation by interacting and travelling with RNA polymerase II from the distal to proximal regions of transcription start sites (Horisawa et al., 2020)

Systematic reviews note that existing human data comes largely from small observational studies or case reports, many with methodological limitations

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Sharma D, De Falco L, Padavattan S, Rao C, Geifman-Shochat S, Liu CF, et al

Class distributions for both binary labels and ternary PPDB levels are similar in all cases, which indicates that no splitting method introduces unwanted additional imbalance