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de Monchaux Oliveira C, Morael J, Guille A, Amadieu C, Vancassel S, Gaudout D, Capuron L, Pourtau L, Castanon N (2023) Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice

Mild liver stress : less than oral steroids but not zero, particularly with more potent compounds at higher doses

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doi: 10.1016/j.brainresbull.2008.03.015

have demonstrated that HIF-1 promotes bone resorption mediated by osteoclasts (OCs), while angiopoietin-like 4 (ANGPTL4) compensates for HIF-1s inadequate stimulation of OC activity and promotes the proliferation and differentiation of osteoblasts (OBs) (138)