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Search strategy Two reviewers (LM, DF) systematically searched MEDLINE, Embase, and the Cochrane Library from inception to August 2023 using a comprehensive search strategy combining study design-, intervention-, and diagnosis-related search terms (see Table 1 for a complete list of antioxidants included in the review)

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This study was designed to systematically evaluate the therapeutic potential of GHK-Cu in a dextran sulfate sodium (DSS)-induced murine model of UC, with particular emphasis on elucidating its regulatory effects on the NAD-dependent deacetylase sirtuin-1 (SIRT1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway