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It seems that the direction of effect is consistently spread among studies, usually implicating early gut changes occurring prior to the manifestation of motor symptoms (Georgescu et al., 2016

4.1 Neurotoxic models In MPTP models, elevated levels of ACSL4 and elevated iron levels coexist with ferroptosis (183, 184)

However, we note that some of the observed metabolite changes may not be directly associated with PD, but rather reflect cognition-related changes

Animals were randomly allocated to experimental groups, and surgical procedures were performed under isoflurane anesthesia of SomnoSuite low-flow anesthesia system (Kent Scientific, Torrington, CT, USA)

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