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Moreover, this kind of plasticity implies that the programming of long-term outcomes might arise from brief and subtle changes in the nutritional environment during developmental stages when nutrient demands for growth are still relatively low, like the periconceptional period and early embryogenesis, rather than from significant nutritional deficits during organogenesis and differentiation

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Using an in vivo imaging technique (GlycoCheck) researchers demonstrated an association between reduced glycocalyx thickness and increased central aortic blood pressure, coupled with the observation that a reduced endothelial glycocalyx was also associated with reduced arterial elasticity or increased arterial stiffness (120)

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