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Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a Tethering mechanism: a TWO-SITE INTERACTION MODEL FOR THE Nrf2-Keap1 COMPLEXA TWO-SITE INTERACTION MODEL FOR THE Nrf2-Keap1 COMPLEX

An N2 hermaphrodite stock recently obtained from the Caenorhabditis Genetics Center was used as wild type (N2H) [21]

Keytruda reduced the risk of death by 17% over chemo alone, with patients on the Keytruda plus chemo regimen surviving for a median 12.7 months versus 10.9 months for those receiving chemotherapy alone

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