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Beyond angiogenesis, BPC-157 also modulates the nitric oxide system (which plays a role in tissue protection), increases FAK-paxillin expression (involved in cell adhesion and growth), and has been shown in animal studies to reduce inflammatory cytokines

The peptide works through an entirely different mechanism involving beta-3 adrenergic receptors in adipose tissue, bypassing the growth hormone/IGF-1 axis completely

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33 The clinical efficacy of SAM in the treatment of cholestasis associated with hepatic diseases has been reviewed