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systematically revealed the dynamic changes in the gut microbiota induced by high-fat feeding and found that gut bacteria produce superoxide anions, which induce damage to intestinal epithelial cells, leading to intestinal barrier dysfunction and exacerbating downstream hepatic steatosis (107)

Tauqir S, Israr M, Rauf B, et al

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On the other hand, conventional breeding, though limited in its potential for folate level improvement, is promising, as it might face lower regulatory restrictions compared with genetic engineering, hence allowing a more rapid implementation in agriculture, reaching the populations in need 756