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Notably, LPS stimulation compromised mitochondrial energy metabolism in macrophages, as evidenced by a 65.7% decrease in ATP content, 33.2% decrease in NAD + content, and 27.5% reduction in the NAD/NADH ratio compared to the control group

Damage-specific DNA-binding protein 1

2021;4:e202000903

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Damage to the cell membrane generates arachidonic acid, followed by the formation of aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal