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The 100mg cohort showed statistically significant reductions in visceral adipose tissue (8.3% vs baseline) and improvements in insulin sensitivity (HOMA-IR reduction of 18.7%), but no hepatotoxicity signals emerged across any dose tier

And enhances mitochondrial function, thermogenesis, and fat oxidation

They can be a reasonable supportive adjunct within a program, and they can correct genuine nutrient deficiencies

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Similar to the effects of NNMT overexpression, hepatocytes treated with MNAM exhibited significant increases in glucose production and expression of Sirt1, G6pc, and Pck1